The science on Amanita muscaria

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Different Compounds In Pantherina
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The Ibotenic Acid Studies Are Incomplete
22:28

The Ibotenic Acid Studies Are Incomplete

Help support this website: BUY ME A CUP OF COFFEE- https://www.buymeacoffee.com/amanitadreamer Monthly Zoom meetings with Patrons: https://www.patreon.com/AmanitaDreamer ETSY Store: https://linktr.ee/AmanitaDreamer STICKERS! Lots of mushrooms STICKERS! On Redbubble https://www.redbubble.com/i/sticker/Amanita-Dreamer-s-Mushroom-Mania-by-AmanitaDreamer/71310436.EJUG5 Get your very own mushroom gear at https://teespring.com/stores/amanita-dreamer Bitcoin:1BUVG3jyxyFRpbXpTRBsaFjEzPmDswN5wC BCH bitcoincash:qpaysup7xynpxrvu9n933p964kdcjgyx2urvle0t4a Instagram: #amanitadreamer Our forum and research wiki: forum.amanitaresearch.com Facebook: https://www.facebook.com/AmanitaDreamer/ Amanita Dreamer PO Box 1131 Ball Ground, GA 30107 The name of the study is The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat AND interestingly they found NO damage to the brain even though it was injected which lends creedence to what I have continued to say, injecting it straight into a brain is not the same thing as ingesting it. I will continue to claim personally that it is NOT toxic at low and reasonable doses. i posted here before on Ibotenic acid and defended this claim. WTF is science's obsession with injecting shit FFS? I am skeptical of this study when they do like many researchers and discuss at great length, the amatoxins in the deadly amanitas then jump right into discussing how they are going to test muscaria. These are two different living things, with different morphologies and physiologies. Muscariods to do not have amatoxins. It is irresponsible science. When they do that, I immediately am skeptical of the rest of the study. Not only because if they can’t get the introduction right, what else can they not do correctly? Amanita muscaria appears to be the most toxic in appearance, with muscarine and bufotenine being the main constituents causing vomiting and diarrhea and exhibiting neuropsychological and psychological effects by muscarine [7,18] Saying muscaria appears to be the most toxic is just nonsense. They cite numbers 7 and 18 in their citations for claiming muscarine and bufotenine are the main constituents causing sickness. Number 7 doesn’t mention muscaroids or muscarine. Number 18 again discusses the class of amanitins, and nothing in that publications mentions muscarine or bufotenine. It was established long ago that muscarine is not the main toxin responsible for gastric issues in the muscaroids. There is no date on this research but they cite research from 2007 so it is at least reasonable to expect some simple research into the actual toxin here. There are only trace amounts of muscarine in muscaroids. Not saying it can’t cause issues, but their claims of it being the main toxin are decades old and wrong. And bufotenine? Seriously? They bought amanita muscaria and extracted at room temp using a buffered solution so that no decarb would take place. This means it was mostly ibotenic acid that they are testing. In the results and discussion they write about ibotenic acid in para 7. In the next paragraph they write this: The blood analysis values of the administration group were significantly different from those of the control group, and all of the SD rats used in the experiment were observed to have no abnormality in health. The mushroom poisoning showed fulminant hepatic necrosis and acute renal failure due to amatoxin, a deadly toxin contained in mushrooms. So now it’s amatoxins they administered? Under the histopathological section, they state that no brain lesions were found. This is not what all previous studies have said about ibo being neurotoxic but those were injected into the brains. It seems injection into the body creates a different physiology (which I think we all expected). They go on to state: There are many ways to classify poisons, but according to the symptoms, they are classified into seven groups, each of which exhibits characteristic latent period, target organ, and clinical symptoms [16,18,24]. The symptoms of poisoning by poisonous mushrooms vary according to the toxic substances contained in the mushroom, and the mushrooms contain a variety of chemical components. Poisoning toxicity is mainly caused by A. phalloides, A. virosa, and A. verna in the genus Amanita, phalloidin and amatoxin in the mushroom contain two types of poisons. Phalloidin acts on the actin polymerase-depolymerase cycle, which causes cell membrane dysfunction, but this is not clinically important. Amatoxin inhibits nucleoplasmic RNA polymerase, Inhibits protein synthesis and can cause necrosis of intestinal epithelial cells, hepatocytes, and kidney tubular cells [2,4,18,21]. Histopathological examination of SD rats repeatedly administered for 3 weeks or more showed degeneration and division of pericytes in the liver tissue. However, A. muscaria seems to induce toxic pathologic lesions in the liver when repeatedly administered over a long period of time, considering that damaged tissues can not be found in the liver tissues of SD rats that were autopsied 1 week and 2 weeks after administration. Serum BUN and creatinine levels were normal in the kidney, but histopathological examination revealed the infiltration of inflammatory cells and necrosis of tubular epithelial cells. Again mixing amatoxins with ibotenic acid. I believe they may have ordered amanita muscaria, especially if that’s what they wanted to study. And it may be possible that’s what they used for this study and that means the actual data may be accurate. IF SO then it seems there’s no brain issues but there are with liver and kidney after 3 weeks of heavy use of dried amanita extracted at room temp and ph controlled. Long term ingestion: A. muscaria was administered at a concentration of 16.5 mg/kg twice a week for 4 weeks. If my math is right that’s: 16.5 mg = .0164g per kg 150 pound person= 68kg 68kg X .0164g = 1.11 grams twice a week for 4 weeks. This is ibotenic acid. This is a good start. That’s a LOT to eat raw on a regular basis. I know people who microdose ibotenic acid for ADD and I smoke the mushroom but have no idea how much decarb happens when it’s burned like that. The people I know microdosing it take 1/5 that. So some dose studies are needed now. I have been asking for this kind of information for a while now. My problem is they seem to lump all toxic amanita together and didn’t even know what toxic thing they were studying. So, still a long way to go. Maybe there’s a bias in the scientific community for ibotenic acid studies and this was a way to get around that. IDK For reference, this is the moderate dose they gave, 1.11 grams, in the photo I’m dropping here. This much twice a week after 3 weeks, they are saying caused damage. I don’t know if the damage healed over time. This is assuming they actually used muscaroids. Please correct anything I’ve said here that’s in error. This is all very important and interesting to me. This study is from 2020 and is about Glutamate toxicity and in the pre-study discussion it gives details about the history of the use excitotoxins including ibotenic acid so you can see all of the different excitotoxins science has used, what they do and why ibotenic acid is being used, still injected into brains. https://www.frontiersin.org/articles/10.3389/fnins.2020.00927/full IBOTENIC ACID AS MEDICINE VanPatten, S.; Al-Abed, Y. The Challenges of Modulating the ‘Rest and Digest’ System: Acetylcholine Receptors as Drug Targets. Drug Discov. Today 2017, 22, 97–104. [Google Scholar]
Heavy Metals And Amanitas
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Heavy Metals And Amanitas

Let's go over what the science has to say about heavy metals and amanitas. Links: I get asked a lot, I'm making a video on this. YT doesn't like links to the outside world and I don't want to risk even a mistaken strike so I'm leaving the links to things I mention in the video, here. Thanks to Neelun for the help in researching Vanadium. It seems that the highly toxic Vanadium Pentoxide is rearranged into Amavadin by Amanita, which is far less toxic and possibly a good bioavailable source. I need to do more research on this and hope that there is further research on all this. Anitoxidants for vanadium https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973198/ The A. muscaria Poland study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133115/ https://pubmed.ncbi.nlm.nih.gov/28121270/ https://pubmed.ncbi.nlm.nih.gov/27984821/ https://pubmed.ncbi.nlm.nih.gov/29746791/ https://pubmed.ncbi.nlm.nih.gov/17849303/ Boiling reduces https://pubmed.ncbi.nlm.nih.gov/28386890/ Pickling https://pubmed.ncbi.nlm.nih.gov/28766143/ Chelation therapy https://www.atsdr.cdc.gov/csem/csem.asp?csem=6&po=12 Cadmium takes chronic exposure to affect human body https://www.atsdr.cdc.gov/csem/csem.asp?csem=6&po=12 Effectivenness of antioxidants and foods on heavy metals toxicity in the body https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303853/ Heavy metals in Panterina in Macedonia https://www.researchgate.net/publicatio ... _Macedonia Different Amanita Species uptake of metals http://www.amanitaceae.org/?Trace%20Elements Different metals in muscaria Upland/lowland regions of Poland https://www.tandfonline.com/doi/abs/10. ... 17.1261547 Also poland https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133115/ Edible mushrooms, different toxic conditions https://www.jstage.jst.go.jp/article/an ... 7_747/_pdf Changes in amounts of metals in stages of development A. muscaria https://www.sciencedirect.com/science/a ... 4620300209 Metals in street dust in Turkey https://pubmed.ncbi.nlm.nih.gov/31388947/ Metals in street dust in China https://link.springer.com/article/10.10 ... 20-09771-4 In the US, Africa, Australia, Europe and North and South America heavy metal pollution from traffic runoff https://pubmed.ncbi.nlm.nih.gov/26448594/ Heavy metals in herbicides https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756058/ (see 2.6) Metals found in corporate cigarettes Several heavy metals found in tobacco smoke, such as Cd, Cr, Pb, and Ni, Notice the words tobacco and cigarettes are used interchangeably when they are not inter changable. Levels are dependent on soil. https://www.ncbi.nlm.nih.gov/pmc/articl ... $=activity Help support this website: BUY ME A CUP OF COFFEE- https://www.buymeacoffee.com/amanitadreamer Monthly Zoom meetings with Patrons: https://www.patreon.com/AmanitaDreamer ETSY Store: https://linktr.ee/AmanitaDreamer STICKERS! Lots of mushrooms STICKERS! On Redbubble https://www.redbubble.com/i/sticker/Amanita-Dreamer-s-Mushroom-Mania-by-AmanitaDreamer/71310436.EJUG5 Get your very own mushroom gear at https://teespring.com/stores/amanita-dreamer Bitcoin:1BUVG3jyxyFRpbXpTRBsaFjEzPmDswN5wC BCH bitcoincash:qpaysup7xynpxrvu9n933p964kdcjgyx2urvle0t4a Instagram: #amanitadreamer Our forum and research wiki: forum.amanitaresearch.com Facebook: https://www.facebook.com/AmanitaDreamer/ Amanita Dreamer PO Box 1131 Ball Ground, GA 30107
Is Amanita Muscaria Deadly, Toxic, Poisonous_ - YouTube (1080p)